| dc.description.abstract | The aim of the present study was pathological investigation and vaccine efficacy of
Infectious Bursal Disease (IBD) in cockrel at Comilla district. A total 15 different cockrel
farms were selected from different area of Comilla district from December-2013 to June
2014. Among them 5 were selected for pathological study while 10 farms were selected for
the effectiveness of IBD vaccine. The affected birds showed dullness, depressions, anorexia,
ruffled feathers, reluctance to move, trembling, prostration followed by death. There was
whitish diarrhoea in the affected birds. In gross study, there were severe haemorrhages on
leg, thigh and pectoral muscles. Haemorrhages were also found at the junction of
proventriculus and gizzard. All the flocks revealed lesions in the Bursa of fabricius. The
Bursa were found turgid, edematous swollen and haemorrhagic. In addition there were
congested or pale carcasses, swollen kidneys with prominent tubules and enlarged or
congested liver noticed during postmortem examination of the cockrel. There was excess
mucous in intestines.
For histopathological study tissue were collected from Bursa of fabricious and junction of
proventriculus and gizzard of necropsed birds using common surgical materials. The lesions
of bursa of fabricious were characterized by atrophy, lymphocytic depletion and an increase
in the thickness of septae of interfollicular tissue. In severe cases lesions of Bursa of
Fabricius showed fatty degeneration in the bursal follicle, edema between bursal follicles,
necrotic and degenerative changes etc. Necrosis was observed in the bursal follicle. In
addition, vacuolation and cyst-like structures were also found.
For the study of vaccine efficacy, two types of vaccine (Intermediate and Intermediate plus)
from two different renowned company Novarties and Intervet were used. Mortality were
6.33%, 3.5% and 6.0% in farm-3, farm-5 and farm-6 respectively in post vaccination. | en_US |
